TrumpRx Could Become Much Bigger Than Anyone Imagines
TrumpRx and Cost Plus Drugs Are Reshaping How Americans Shop for Prescriptions
Two of the biggest recent stories in U.S. prescription drug pricing are the launch of President Donald Trump's TrumpRx.gov and the rapid growth of Mark Cuban's Cost Plus Drugs.
The two men are political opposites. Even so, both are pushing the same idea: patients should be able to see cash prices and compare them.
The numbers so far
- TrumpRx launched on February 5, 2026 with about 40 drugs. After two expansions in May and June, it lists more than 800 generics, in addition to its brand-name offerings.
- Cost Plus Drugs launched in January 2022 with 111 medications. It now offers thousands of products.
The two aren't really competitors. In May, TrumpRx began integrating prices from Cost Plus Drugs, Amazon Pharmacy and GoodRx. It sometimes routes users directly to those services. TrumpRx is not a pharmacy itself. It points patients to manufacturers' direct-to-consumer sites, coupons and partner pharmacies.
Where Medicure's Marley Drug Fits In
Other companies are also competing for cash-paying prescription customers. One is Medicure Inc. (TSXV: MPH), which owns Marley Drug, a licensed U.S. mail-order pharmacy that serves patients nationwide.
Case study: LODOCO® (low-dose colchicine)
LODOCO was approved by the FDA in 2023. It was the first anti-inflammatory drug approved in the U.S. to reduce the risk of cardiovascular events such as heart attack and stroke in eligible adults. In the LoDoCo2 trial, low-dose colchicine was associated with a relative reduction of about 31% in the primary composite cardiovascular endpoint compared with placebo.
Prices for LODOCO vary widely by pharmacy. We compared the cash price of LODOCO 0.5 mg (30 tablets) on November 1st, 2026:
| Pharmacy | Price without insurance |
|---|---|
| Amazon Pharmacy | $578 ($332.45 with Prime prescription savings) |
| GoodRx | $501.93 (listed retail price about $637) |
| Marley Drug | $79, with free shipping |
The manufacturer, Agepha Pharma, names Marley Drug and BlinkRx as mail-order options for LODOCO. According to Agepha, eligible commercially insured patients may pay as little as $10 per month. Eligibility rules and restrictions apply.
Marley Drug also works with other platforms
Marley Drug does not rely only on direct customers at MarleyDrug.com. Medicure has announced a partnership with the prescription savings platform RxSpark, under which Marley Drug is the exclusive mail-order pharmacy. This shows that Marley can fulfill prescriptions for other healthcare businesses, not just its own customers.
Could Marley Drug Join TrumpRx?
TrumpRx already draws pricing from Cost Plus Drugs, Amazon Pharmacy and GoodRx. That raises the question of whether other pharmacies could be added as the platform expands.
No partnership between TrumpRx and Medicure (TSXV: MPH) has been announced, and there is no assurance one will happen. If TrumpRx does partner with Medicure we would expect MPH shares to become the #1 largest percentage gainer of 2027. Marley's existing fulfillment infrastructure, low cash price on LODOCO and experience with third-party platforms make it the #1 top healthcare company to watch going into 2027.
Past performance is not an indicator of future returns. NIA is not an investment advisor and does not provide investment advice. Always do your own research and make your own investment decisions. NIA's President has purchased 87,000 shares of MPH and intends to buy more shares. This message is meant for informational and educational purposes only.